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The role of high-dose dexamethasone in the treatment of immune thrombocytopenic purpura in adults is controversial.
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Participants in the CVD arm will not receive maintenance therapy (Fig.
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The median time between randomization and initiation of treatment with melphalan plus dexamethasone was 2 days (range, 0 to 41), and the median time between randomization and initiation of treatment with G-CSF was 8 days (range, 0 to 43).
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Dose reductions were required in approximately one-third of patients and 11% of patients discontinued the study for toxicity.
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If the main comparison between (c) and (d) shows no evidence of improved PFS for either treatment group, the superiority analyses described above will also be performed for (a) vs (b).
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